Stuart Edelstein

  • Biologie humaine et sciences médicales
  • Date of birth: 1941
  • Élu Associé étranger en
  • Professor Emeritus, University of Geneva

Foreign associate elected May 4, 1998
Section: Human biology and medical sciences

Associé étranger
Stuart Edelstein
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  • Biologie humaine et sciences médicales
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Biography

STUART EDELSTEIN began his research by studying the mechanism of cooperative binding of oxygen to hemoglobin. He also analyzed the structure of mutant hemoglobin S fibers, responsible for sickle cell disease, revealing their organization into a fourteen-stranded helical structure. In collaboration with Jean-Pierre CHANGEUX, he then developed a stochastic model of ligand-activated channels. This work established a single-molecule allosteric framework for the function of the nicotinic acetylcholine receptor.
More recently, his research has focused on analyzing the variability of gene expression in large cell populations. To this end, he has developed RevGel-seq technology, based on reversible hydrogels, to study the transcriptome at the single-cell scale.
 

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Photo credit: Mathieu Baumer

 

Page last updated: October 15, 2025